Activation of the trans geometry in platinum antitumor complexes.
β Scribed by M. van Beusichem; A.P.Soares Fontes; J.D. Roberts; L.R. Kelland; N. Farrell
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- English
- Weight
- 92 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0162-0134
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Contemporary ideas about the mechanism of antitumor activity of platinum complexes are reviewed and discussed. The induction of SOS functions in bacteria is emphasized and an analogous mechanism in animal cells is suggested. The fate of the leaving ligand in the body is not known. Therefore the comp
In order to examine the structureactivity relationship between the platinum complexes having a bidentate ligand as non-leaving group dichloro 2aminomethylpiperidine Pt(II), PtCla(2ampip) dichloro 3-aminomethylpiperidine Pt(II), PtCla-(3ampip), and dichloro 2aminomethylpyridine Pt(II), PtClz(2-ampy),