Trans geometry in platinum antitumor complexes
β Scribed by Urszula Kalinowska-Lis; Justyn Ochocki; Ksenia Matlawska-Wasowska
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 907 KB
- Volume
- 252
- Category
- Article
- ISSN
- 0010-8545
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## Abstract Substitution of NH~3~ by a range of amines in __trans__β[PtCl~2~(NH~3~)~2~] produces compounds with cytotoxicity significantly improved over the parent transplatin and in many cases equivalent to that of cisplatin. This microreview summarizes the chemistry and biology of __trans__βplati
Contemporary ideas about the mechanism of antitumor activity of platinum complexes are reviewed and discussed. The induction of SOS functions in bacteria is emphasized and an analogous mechanism in animal cells is suggested. The fate of the leaving ligand in the body is not known. Therefore the comp
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a βFull Textβ option. The original article is trackable v