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Activation of p53 DNA binding activity by point mutation

✍ Scribed by Marston, Nicola J; Ludwig, Robert L; Vousden, Karen H


Book ID
110061362
Publisher
Nature Publishing Group
Year
1998
Tongue
English
Weight
419 KB
Volume
16
Category
Article
ISSN
0950-9232

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The transcription factor p53 controls the proliferation and survival of cells exposed to DNA damage. The specific DNA-binding domain of p53 (residues 102-292) has a complex tertiary structure that is stabilized by zinc. In this study, we showed that exposure of cultured cells to the membrane-permeab