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P-TEFb inhibitors interfere with activation of p53 by DNA-damaging agents

โœ Scribed by Radhakrishnan, S K; Bhat, U G; Halasi, M; Gartel, A L

Book ID
110072726
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
188 KB
Volume
27
Category
Article
ISSN
0950-9232

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## Abstract Ascochlorin, a prenylphenol antitumor antibiotic, profoundly increases the expression of endogenous p53 by increasing protein stability in the human osteosarcoma cells and human colon cancer cells. Ascochlorin also increases DNA binding activity to the p53 consensus sequence in nuclear