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Maintenance of genomic integrity by p53: complementary roles for activated and non-activated p53

✍ Scribed by Albrechtsen, Nils; Dornreiter, Irene; Grosse, Frank; Kim, Ella; Wiesmüller, Lisa; Deppert, Wolfgang

Book ID
110062349
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
866 KB
Volume
18
Category
Article
ISSN
0950-9232

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✍ Xiao-Chun Zhang; Jian Chen; Chun-Hui Su; Heng-Yin Yang; Mong-Hong Lee 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 386 KB

## Abstract The 5th subunit of COP9 signalosome (CSN5, also known as Jab1 or COPS5) is implicated in regulating p53 activity and is overexpressed in various tumors. However, the precise roles of CSN5 in p53 network and tumorigenesis are not well characterized. Here we show that CSN5 is a critical r