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Direct transactivation of c-Ha-Ras gene by p53: evidence for its involvement in p53 transactivation activity and p53-mediated apoptosis

✍ Scribed by Deguin-Chambon, Valérie; Vacher, Monique; Jullien, Martial; May, Evelyne; Bourdon, Jean-Christophe

Book ID
110064273
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
260 KB
Volume
19
Category
Article
ISSN
0950-9232

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Exposure to aflatoxin B 1 (AFB 1 ) is one of the risk factors for developing hepatoma. In rats, activation of the ras gene is a prevalent event in AFB 1 -induced hepatocarcinogenesis. It is not clear whether a similar event occurs in humans. By analysis of codon 249 of the p53 gene, six of 36 human