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Activated protein C resistance caused by factor V gene mutation: Common coagulation defect in chronic venous leg ulcers?

✍ Scribed by Dominik Peus; John A. Heit; Mark R. Pittelkow

Book ID: 117395827
Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 495 KB
Volume: 36
Category: Article
ISSN: 1097-6787
DOI: 10.1016/s0190-9622(97)70251-2

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Hereditary predisposition to thrombosis due to activated protein C resistance (APCR) has been attributed to a missense mutation in the factor V gene at nucleotide 1691 (G to A), causing replacement of arginine at codon 506 with glutamine. Using an RFLP-PCR assay to detect this mutation, we measured