𝔖 Bobbio Scriptorium
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ACTIVATED PROTEIN C RESISTANCE CAUSED BY A COMMON FACTOR V MUTATION HAS A SINGLE ORIGIN.

✍ Scribed by Bengt Zöller; Andreas Hillarp; Björn Dahlbäck


Book ID
117258664
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
991 KB
Volume
85
Category
Article
ISSN
0049-3848

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Detection of a common mutation in factor
✍ A. Ferreira-Gonzalez; LM Fisher; CM Lehman; MH Langley; DH Lofland; Q Xia; NX Ng 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 119 KB 👁 1 views

Hereditary predisposition to thrombosis due to activated protein C resistance (APCR) has been attributed to a missense mutation in the factor V gene at nucleotide 1691 (G to A), causing replacement of arginine at codon 506 with glutamine. Using an RFLP-PCR assay to detect this mutation, we measured