Acetylcholine-activated inward current induces cytosolic Ca2+ mobilization in mouse C2C12 myotubes
β Scribed by A. Giovannelli; F. Grassi; C. Limatola; E. Mattei; D. Ragozzino; F. Eusebi
- Book ID
- 113236733
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 909 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0143-4160
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
In cultured mouse C2C12 myotubes, digital Ca 2+ imaging fluorescence microscopy using the acetoxymethyl ester of Fura-2, Fura-2-AM, showed that, in the absence of extracellular Ca 2+, acetylcholine (ACh) and nicotine, but not muscarine, raised the intracellular concentration of Ca 2 + ([Ca 2 +]i) by
## Abstract Protein kinase C (PKC) activity has been implicated in nicotinic acetylcholine receptor (nAChR) cluster disruption but the specific PKC isoforms involved have not been identified. We first tested whether phorbol esters, which activate PKCs, regulate agrinβinduced nAChR clustering in C~2