## Abstract We consider three tests for genetic association in data from nuclear families (the FamilyβBased Association Test (FBAT) test proposed by Rabinowitz and Laird ([2000] Hum. Hered. 50:211β223), a second test proposed by Rabinowitz ([2002] J. Am. Stat. Assoc. 97:742β758), and the Family Gen
Accounting for Linkage in Family-Based Tests of Association with Missing Parental Genotypes
β Scribed by Eden R. Martin; Meredyth P. Bass; Elizabeth R. Hauser; Norman L. Kaplan
- Book ID
- 117854310
- Publisher
- American Society of Human Genetics
- Year
- 2003
- Tongue
- English
- Weight
- 343 KB
- Volume
- 73
- Category
- Article
- ISSN
- 0002-9297
- DOI
- 10.1086/378779
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The development of a new method for testing the association of genetic markers with disease is presented. This approach is applicable when sampling nuclear families with one or more affected siblings and when neither, one, or both parents are missing marker genotype data. All siblings, affected and
## Abstract Linkage and association analyses have played important roles in identifying susceptibility genes for complex diseases. Linkage tests and familyβbased tests of association are often applied in the same data to help fineβmap disease loci or validate results. This paradigm increases effici