Family-Based Association Tests Incorporating Parental Genotypes
โ Scribed by Peter Kraft; Melissa Wilson
- Book ID
- 117854036
- Publisher
- American Society of Human Genetics
- Year
- 2002
- Tongue
- English
- Weight
- 56 KB
- Volume
- 71
- Category
- Article
- ISSN
- 0002-9297
- DOI
- 10.1086/344142
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## Abstract We consider three tests for genetic association in data from nuclear families (the FamilyโBased Association Test (FBAT) test proposed by Rabinowitz and Laird ([2000] Hum. Hered. 50:211โ223), a second test proposed by Rabinowitz ([2002] J. Am. Stat. Assoc. 97:742โ758), and the Family Gen
The development of a new method for testing the association of genetic markers with disease is presented. This approach is applicable when sampling nuclear families with one or more affected siblings and when neither, one, or both parents are missing marker genotype data. All siblings, affected and