We use likelihood-based score statistics to test for association between a disease and a diallelic polymorphism, based on data from arbitrary types of nuclear families. The Nonfounder statistic extends the transmission disequilibrium test (TDT) to accommodate affected and unaffected offspring, missi
Family-based association tests using genotype data with uncertainty
β Scribed by Yu, Z.
- Book ID
- 111886786
- Publisher
- Oxford University Press
- Year
- 2011
- Tongue
- English
- Weight
- 221 KB
- Volume
- 13
- Category
- Article
- ISSN
- 1465-4644
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## Abstract Familyβbased study designs have an important role in the search for association between disease phenotypes and genetic markers. Unlike traditional caseβcontrol methods, familyβbased tests use withinβfamily data to avoid identification of spurious associations that may result from popula
## Abstract We consider three tests for genetic association in data from nuclear families (the FamilyβBased Association Test (FBAT) test proposed by Rabinowitz and Laird ([2000] Hum. Hered. 50:211β223), a second test proposed by Rabinowitz ([2002] J. Am. Stat. Assoc. 97:742β758), and the Family Gen
## Abstract Based on the symmetry of transmitted/nontransmitted alleles from heterozygous parents under the null hypothesis of no association, the work proposed here establishes a general statistical framework for constructing association tests with data from nuclear families with multiple affected