For metabolic studies in this Laboratory, 5-hydroxytryptamine (serotonin) labelled with I4C in the pyrrole part of the indole ring was required. Previous attempts to reach this compound through Madelung cyclization of 3-benzyloxy--6-formylaminotoluene failed (I), although this way proved to be succe
Access to 14C-Ring labelled phenothiazines. Synthesis of 2-chlorophenolhiazine-5a,9-14C
✍ Scribed by Richard R. Muccino; Joseph Cupano; Arnold A. Liebman
- Book ID
- 112125651
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 1979
- Tongue
- English
- Weight
- 152 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0022-152X
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## Abstract p‐Toluic acid‐ring‐^14^C was synthesized by the Friedel‐Crafts p‐carbamylation of toluene‐ring‐^14^C with N,N‐disubstituted carbamyl chloride and subsequent hydrolysis. The radiochemical yield was 61%. An attempt was made to apply this method for the synthesis of benzoic acid‐ring‐^14^C
## Abstract A synthetic procedure for C‐14‐labeled N‐methyl‐N‐nitrosoaniline is presented. Separate labeling of the methyl and phenyl side chains was achieved by using C‐14‐labeled methyl iodide and aniline, respectively. The overall yield of the four reactions was 62% and the final products were s