Synthesis of [2-14C]-labelled 2,2′-anhydrouridine and 2'-deoxyuridine derivatives. A convenient route to [2-14C]-labelled 5-ethynyl- and 5-ethyl-2′-deoxyuridine
✍ Scribed by Jerzy Giziewicz; Lajos J. Gati; Edward E. Knaus; John R. Mercer; Richard J. Flanagan; Leonard I. Wiebe
- Book ID
- 107769351
- Publisher
- Elsevier Science
- Year
- 1985
- Weight
- 526 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0020-708X
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## Abstract [2‐^14^C]5‐Allyl‐2′‐deoxyuridine was synthesized directly from [2‐^14^C]2′‐deoxyuridine using mercury, palladium, and 3‐chloropropene. [2‐^14^C]5‐Propyl‐2′‐deoxyuridine was obtained by hydrogenation of the [^14^C]5‐allyl‐2′‐deoxy‐uridine. Advantages of the synthetic method and its appli
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## Abstract The synthesis and preliminary biological evaluation of a lipophilic, fluorine‐18‐labeled 5‐ethynyl‐2′‐deoxyuridine derivative [^18^F]‐**3** is described. Initially, 5‐ethynyl‐2′‐deoxyuridine **5** was synthesized by coupling trimethylsilyl protected acetylene to 5‐iodo‐2′‐deoxyuridine *
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