## Abstract Theophylline, a cyclic nucleotide phosphodiesterase inhibitor, increases the rate of tyrosine aminotransferase (TAT) degradation in rat hepatoma tissue culture (HTC) cells. Theophylline (0.1β10 mM) causes a twoβ to fiveβfold increase in intracellular cAMP concentration but a 30β60% decr
Acceleration of the degradation of tyrosine aminotransferase in rat hepatoma (HTC) cells by inhibitors of cyclic nucleotide phosphodiesterase
β Scribed by Robert H. Stellwagen; Rochelle D. Sailor; Kulwant K. Kohli
- Book ID
- 118311939
- Publisher
- Elsevier Science
- Year
- 1977
- Tongue
- English
- Weight
- 324 KB
- Volume
- 78
- Category
- Article
- ISSN
- 0006-291X
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## Abstract The increase in tyrosine aminotransferase activity which occurs in rat hepatoma tissue culture (HTC) cells in response to cyclic AMP analogs has been shown to be an enzyme induction, similar to the larger response observed in certain other hepatoma cells and in liver. A specific antibod
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