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Induction of tyrosine aminotransferase by dibutyryl cyclic-AMP employing hepatoma cells in tissue culture

โœ Scribed by F.R. Butcher; J.E. Becker; V.R. Potter

Book ID
118875880
Publisher
Elsevier Science
Year
1971
Tongue
English
Weight
578 KB
Volume
66
Category
Article
ISSN
0014-4827

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## Abstract Theophylline, a cyclic nucleotide phosphodiesterase inhibitor, increases the rate of tyrosine aminotransferase (TAT) degradation in rat hepatoma tissue culture (HTC) cells. Theophylline (0.1โ€“10 mM) causes a twoโ€ to fiveโ€fold increase in intracellular cAMP concentration but a 30โ€“60% decr