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Insulin-mediated regulation of tyrosine aminotransferase in rat hepatoma cells: Inhibition of transcription and inhibition of enzyme degradation

✍ Scribed by Patrick S. Moore; John W. Koontz

Book ID
115708222
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
986 KB
Volume
275
Category
Article
ISSN
0003-9861

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## Abstract Theophylline, a cyclic nucleotide phosphodiesterase inhibitor, increases the rate of tyrosine aminotransferase (TAT) degradation in rat hepatoma tissue culture (HTC) cells. Theophylline (0.1–10 mM) causes a two‐ to five‐fold increase in intracellular cAMP concentration but a 30–60% decr