Inhibition of steroid inducible tyrosine aminotransferase by Mouse and rat interferon in hepatoma tissue culture cells
✍ Scribed by Gisèle Beck; Philippe Poindron; Dominique Illinger; Jean-Paul Beck; Jean-Pierre Ebel; Rebecca Falcoff
- Book ID
- 115904515
- Publisher
- Elsevier Science
- Year
- 1974
- Tongue
- English
- Weight
- 263 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0014-5793
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## Abstract The role of the nucleus in bringing about the induction of tyrosine aminotransferase (TAT) by glucocorticosteroid hormone and its deinduction upon steroid removal has been studied in enucleated rat hepatoma tissue culture cells (FU5–5). Both processes require the presence of the nucleus
## Abstract Theophylline, a cyclic nucleotide phosphodiesterase inhibitor, increases the rate of tyrosine aminotransferase (TAT) degradation in rat hepatoma tissue culture (HTC) cells. Theophylline (0.1–10 mM) causes a two‐ to five‐fold increase in intracellular cAMP concentration but a 30–60% decr