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Accelerating Effect Induced by the Structure of α-Amino Acid in the Copper-Catalyzed Coupling Reaction of Aryl Halides with α-Amino Acids. Synthesis of Benzolactam-V8

✍ Scribed by Ma, Dawei; Zhang, Yongda; Yao, Jiangchao; Wu, Shihui; Tao, Fenggang

Book ID
111685119
Publisher
American Chemical Society
Year
1998
Tongue
English
Weight
206 KB
Volume
120
Category
Article
ISSN
0002-7863

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We have developed an efficient method for the preparation of enantiopure N-aryl-a-amino acids via copper-catalyzed N-arylation of a-amino acids and aryl halides under microwave irradiation. This protocol only needs less than 30 min to obtain the products, which are far superior to those obtained und

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