Germline mutations in the tumor-suppresor APC gene are associated with hereditary familial adenomatous polyposis (FAP) and somatic mutations are common in sporadic colorectal cancer. In this study, we report the identification of three novel germline mutations: 1682-1683insA, 3252-3253insAT, 3544A>T
Absence of somatic alterations of the EB1 gene adenomatous polyposis coli-associated protein in human sporadic colorectal cancers
✍ Scribed by Jaïs, P; Sabourin, J-C; Bombled, J; Rougier, P; Lasser, P; Duvillard, P; Bénard, J; Bressac-de Paillerets, B
- Book ID
- 109838678
- Publisher
- Nature Publishing Group
- Year
- 1998
- Tongue
- English
- Weight
- 851 KB
- Volume
- 78
- Category
- Article
- ISSN
- 0007-0920
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Germline mutations of the putative tumor suppressor gene APC are associated in high frequency with the familial adenomatous polyposis, predisposing the patients to colorectal neoplasia. Similarly, sequence analyses have revealed that in more than half of patients with sporadic colorectal carcinoma o
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