Somatic alterations of the SMAD-2 gene in human colorectal cancers
β Scribed by Takagi, Y; Koumura, H; Futamura, M; Aoki, S; Ymaguchi, K; Kida, H; Tanemura, H; Shimokawa, K; Saji, S
- Book ID
- 109838653
- Publisher
- Nature Publishing Group
- Year
- 1998
- Tongue
- English
- Weight
- 677 KB
- Volume
- 78
- Category
- Article
- ISSN
- 0007-0920
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Escape from transforming growth factor-β€ (TGF-β€)induced inhibition of proliferation has been observed in many tumor cells and may contribute to loss of growth control. Smad proteins have been identified as major components in the intracellular signaling of TGF-β€ family members. In this study, we exa
The p16 INK4A gene, which encodes the cell-cycle regulatory protein cyclin-dependent kinase 4 inhibitor, is a putative tumor-suppressor gene. We examined p16 gene alterations in 30 primary ovarian cancers and 11 ovarian cancer cell lines. Five of the primary cancers (16.7%) had lost both p16 INK4A g