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Absence of cyclin D2 expression is associated with promoter hypermethylation in gastric cancer

✍ Scribed by Yu, J; Leung, W K; Ebert, M P A; Leong, R W L; Tse, P C H; Chan, M W Y; Bai, A H C; To, K F; Malfertheiner, P; Sung, J J Y


Book ID
109997570
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
344 KB
Volume
88
Category
Article
ISSN
0007-0920

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Promoter hypermethylation of MGMT is ass
✍ Naohide Oue; Hideo Shigeishi; Hiroki Kuniyasu; Hiroshi Yokozaki; Kazuya Kuraoka; πŸ“‚ Article πŸ“… 2001 πŸ› John Wiley and Sons 🌐 French βš– 83 KB πŸ‘ 1 views

Aberrant methylation of CpG islands within promoter regions is associated with transcriptional inactivation of various tumor suppressor genes in neoplasms. Recently, O 6 -methylguanine-DNA methyltransferase, MGMT, was shown to be hypermethylated in certain carcinomas, resulting in loss of MGMT prote