Promoter hypermethylation of MGMT is ass
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Naohide Oue; Hideo Shigeishi; Hiroki Kuniyasu; Hiroshi Yokozaki; Kazuya Kuraoka;
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Article
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2001
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John Wiley and Sons
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French
β 83 KB
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Aberrant methylation of CpG islands within promoter regions is associated with transcriptional inactivation of various tumor suppressor genes in neoplasms. Recently, O 6 -methylguanine-DNA methyltransferase, MGMT, was shown to be hypermethylated in certain carcinomas, resulting in loss of MGMT prote