Promoter methylation status of the Cyclin D2 gene is associated with poor prognosis in human epithelial ovarian cancer
β Scribed by Michiko Sakuma; Jun-ichi Akahira; Kiyoshi Ito; Hitoshi Niikura; Takuya Moriya; Kunihiro Okamura; Hironobu Sasano; Nobuo Yaegashi
- Book ID
- 108583818
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 356 KB
- Volume
- 98
- Category
- Article
- ISSN
- 1347-9032
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
A subset of these data has been published-Dl7S5 (47 patients) and D17S74 (40 patients) (Leary et al., 1993).
## Abstract ## BACKGROUND: Abnormal activation of the Wnt/Ξ²βcatenin signaling pathway is common and critical in the pathogenesis of digestive cancers. In this study, the authors investigated the promoter methylation of the dickkopf homolog 3 gene __Dkkβ3__ in these cancers and its prognostic signi
Paraffin sections from 190 epithelial ovarian tumours, including 159 malignant and 31 benign epithelial tumours, were analysed immunohistochemically for expression of cyclin-dependent kinase inhibitor 2 (CDKN2A) gene product p16 INK4A (p16). Most benign tumours showed no p16 expression in the tumour