Hydrogen Bonds and the Catalytic Mechani
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SILKE THOMS
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Article
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2002
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Elsevier Science
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English
β 142 KB
A new model for catalysis of human carbonic anhydrase II is suggested. The model is based on the X-ray structure of the hydrogen bond network in the catalytic site. The outer part of the network is proposed to adjust the pK a of the catalytic site to the experimentally observed value of about 7. The