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About the Kinetic Feasibility of the Lipscomb Mechanism in Human Carbonic Anhydrase II

✍ Scribed by Tautermann, Christofer S.; Loferer, Markus J.; Voegele, Andreas F.; Liedl, Klaus R.


Book ID
127256292
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
269 KB
Volume
107
Category
Article
ISSN
0022-3654

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A new model for catalysis of human carbonic anhydrase II is suggested. The model is based on the X-ray structure of the hydrogen bond network in the catalytic site. The outer part of the network is proposed to adjust the pK a of the catalytic site to the experimentally observed value of about 7. The