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Hydration of carbon dioxide by carbonic anhydrase: intramolecular proton transfer between zinc-bound water and histidine 64 in human carbonic anhydrase II

โœ Scribed by Liang, Jiin Yun; Lipscomb, William N.


Book ID
125974528
Publisher
American Chemical Society
Year
1988
Tongue
English
Weight
826 KB
Volume
27
Category
Article
ISSN
0006-2960

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Positions of His-64 and a bound water in
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## Abstract The 3โ€dimensional structure of human carbonic anhydrase II (HCAII; EC 4.2.1.1) complexed with 3 structurally related inhibitors, __la, lb__, and __lc__, has been determined by Xโ€ray crystallographic methods. The 3 inhibitors (__la__ = C~8~H~12~N~2~O~4~S~3~) vary only in the length of th