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Aberrant Hypermethylation of p14ARF and O6-methylguanine-DNA Methyltransferase Genes in Astrocytoma Progression

✍ Scribed by Takao Watanabe; Yoichi Katayama; Atsuo Yoshino; Kazunari Yachi; Takashi Ohta; Akiyoshi Ogino; Chiaki Komine; Takao Fukushima


Book ID
111404401
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
183 KB
Volume
17
Category
Article
ISSN
1015-6305

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## Abstract Promotor hypermethylation is a common event in human cancer. __O^6^‐Methylguanine‐DNA Methyltransferase__ (__MGMT__) is a gene involved in DNA repair, which is methylated in a variety of cancer types. In colorectal cancer and lung cancer, hypermethylation of __MGMT__ has been correlated