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A Versatile Linkage Strategy for Solid-Phase Synthesis of N , N -Dimethyltryptamines and β-Carbolines

✍ Scribed by Wu, Tom Y. H.; Schultz, Peter G.


Book ID
120666017
Publisher
American Chemical Society
Year
2002
Tongue
English
Weight
208 KB
Volume
4
Category
Article
ISSN
1523-7060

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The synthesis of polymer-supported N-Fmoc-dehydroalanine starting from S-protected cysteine via an oxidation/elimination strategy is described. Cycloaddition with a range of dienes aorded a range of conformationally constrained amino acids in moderate yields. The potential applications of this metho