Parallel synthesis of 1,2,4-trisubstitut
✍
James M. Cobb; Neil Grimster; Nawaz Khan; Justine Y.Q. Lai; Helen J. Payne (née
📂
Article
📅
2002
🏛
Elsevier Science
🌐
French
⚖ 154 KB
The synthesis of 1,2,4-trisubstituted imidazoles was demonstrated via the solid phase synthesis of N-alkyl-N-(bketo)amides using a carbazate linker. The approach enabled the assembly of a diverse number of N-alkyl-N-(b-keto)amide intermediates in good yield and purity. Subsequent cyclisation in solu