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Solid-Phase Synthesis of N -Alkyl- N -( β -keto)amides and 1,2,4,5-Tetrasubstituted Imidazoles Using a Traceless Cleavage Strategy

✍ Scribed by Lee, H. Boon; Balasubramanian, Shankar


Book ID
125488948
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
74 KB
Volume
2
Category
Article
ISSN
1523-7060

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Parallel synthesis of 1,2,4-trisubstitut
✍ James M. Cobb; Neil Grimster; Nawaz Khan; Justine Y.Q. Lai; Helen J. Payne (née 📂 Article 📅 2002 🏛 Elsevier Science 🌐 French ⚖ 154 KB

The synthesis of 1,2,4-trisubstituted imidazoles was demonstrated via the solid phase synthesis of N-alkyl-N-(bketo)amides using a carbazate linker. The approach enabled the assembly of a diverse number of N-alkyl-N-(b-keto)amide intermediates in good yield and purity. Subsequent cyclisation in solu