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A versatile family of degradable non-viral gene carriers based on hyperbranched poly(ester amine)s

✍ Scribed by Zhiyuan Zhong; Yan Song; Johan F.J. Engbersen; Martin C. Lok; Wim E. Hennink; Jan Feijen


Book ID
113690997
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
229 KB
Volume
109
Category
Article
ISSN
0168-3659

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## Abstract Polyethylenimine (PEI) is a well‐known cationic polymer which has high transfection efficiency due to its buffering effect. However, nondegradability, cytotoxicity, aggregation, and short‐circulation time __in vivo__ still need to be overcome for a successful gene delivery. Degradable,