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Novel Poly(Ester Amine) Based on Polycaprolactone and Polyethylenimine as a Gene Carrier: Effect of Hydrophobicity on Transfection Efficiency and Cytotoxicity

✍ Scribed by Arote, Rohidas B.; Kim, Tae Hee; Kim, You Kyoung; Jere, Dhananjay; Jiang, Hu Lin; Park, In Young; Cho, Myung Haing; Nah, Jae Woon; Cho, Chong Su

Book ID
120993076
Publisher
Trans Tech Publications, Ltd.
Year
2007
Tongue
English
Weight
260 KB
Volume
342-343
Category
Article
ISSN
1662-9795

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## Abstract Polyethylenimine (PEI) is a well‐known cationic polymer which has high transfection efficiency due to its buffering effect. However, nondegradability, cytotoxicity, aggregation, and short‐circulation time __in vivo__ still need to be overcome for a successful gene delivery. Degradable,