A Validated HPLC Method For the Determination of Carbamazepine and Carbamazepine 10,11-Epoxide in Human Plasma
โ Scribed by Miller, R. Brent; Vranderick, Manon
- Book ID
- 120018518
- Publisher
- Taylor and Francis Group
- Year
- 1993
- Tongue
- English
- Weight
- 415 KB
- Volume
- 16
- Category
- Article
- ISSN
- 1082-6076
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๐ SIMILAR VOLUMES
Carbamazepine-lO,l l-epoxide is a metabolite of carbamazepine that has been identified in the urine OT the rat and in the urine and plasma of marV and which, in the rat, has been shown to have antiepileptic properties comparable to those of the parent drug. It has therefore been suggested3 that, in
A highly-sensitive microcolumn HPLC method for the simultaneous determination of carbamazepine and carbamazepine-l0,ll-epoxide in human serum and saliva is described. The method was successfully employed for the study of pharmacokinetics of carbamazepine in humans. After oral administration of 100 a