✦ LIBER ✦

A unified approach to prostanoid and corticosteroid synthons

✍ Scribed by Steven D. Burke; David R. Magnin; Jeffrey A. Oplinger; Julia P. Baker; Ahmed Abdelmagid

Publisher: Elsevier Science
Year: 1984
Tongue: French
Weight: 321 KB
Volume: 25
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)91137-2

No coin nor oath required. For personal study only.

✦ Synopsis

Synthons for 11-deoxyprostanoids and II-ketosteroids are available via intramolecular Diels-Alder reactions between oxygenated dienes and attached butenolides.

Because of their biological significance, scarcity, and structural diversity, the prostanoid and steroid hormonal agents have held the attention of synthetic chemists for many years.' Reported herein are studies directed at a unified approach to the synthesis of both classes of compounds. The general strategy is based upon the use of the intramolecular Diels-Alder cycloaddition,2 as indicated in eq 1. It was anticipated that the rigid butenolide would effectively transmit dienophile orientation requirements through the tether to the diene, thus favoring the formation of trans-fused hydrindene units as synthons for ll-deoxyprostaglandins and 11-ketosteroids. 3 'H2(1 atm), Lindlar's cat., EtOAc, 25%.

📜 SIMILAR VOLUMES

A new approach to prostanoids

✍ L.K. Truesdale; D. Swanson; R.C. Sun 📂 Article 📅 1985 🏛 Elsevier Science 🌐 French ⚖ 152 KB

Approach to corticosteroid-dependent and

Approach to corticosteroid-dependent and corticosteroid-refractory Crohn's disease

✍ Dr. Gary R. Lichtenstein 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 650 KB

Corticosteroids are considered a drug of choice for the treatment of patients with moderately to severely active Crohn's disease (CD), an inflammatory bowel disease characterized by chronic recurrent flares of disease activity. However, among patients receiving corticosteroid therapy for induction o

A novel approach to the synthesis of pro

A novel approach to the synthesis of prostanoids

✍ Andrew Greene; Pierre Crabbé 📂 Article 📅 1975 🏛 Elsevier Science 🌐 French ⚖ 220 KB

A considerable effort has been devoted to synthetic studies of natural and modified prostaglandinsL'\*. We have been engaged in a research programme having as its objective a new chemical synthesis that would allow access to natural prostaglandins as well as to many modified prostaglandins, not read

A biogenetic approach to the synthesis o

A biogenetic approach to the synthesis of a prostanoid precursor.

✍ E.J. Corey; G.W.J. Fleet; Michiharu Kato 📂 Article 📅 1973 🏛 Elsevier Science 🌐 French ⚖ 221 KB

The endoperoxide II has been shown to be a key intermediate m the synthesis of primary (E and F) prostaglandins from C20 unsaturated fatty acids such as all cis-eicosa-8,11,14-trienoic acid.

A Synthon Approach to Spiro Compounds

✍ Rosy Pradhan; Manabendra Patra; Ajaya K. Behera; Bijay K. Mishra; Rajani K. Behe 📂 Article 📅 2006 🏛 John Wiley and Sons ⚖ 15 KB

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

A unified approach to peptin antibiotics

✍ Marco A. Ciufolini; Delphine Valognes; Ning Xi 📂 Article 📅 1999 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 398 KB