𝔖 Bobbio Scriptorium
✦   LIBER   ✦

A novel approach to the synthesis of prostanoids

✍ Scribed by Andrew Greene; Pierre Crabbé

Publisher
Elsevier Science
Year
1975
Tongue
French
Weight
220 KB
Volume
16
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

A considerable effort has been devoted to synthetic studies of natural and modified prostaglandinsL'*. We have been engaged in a research programme having as its objective a new chemical synthesis that would allow access to natural prostaglandins as well as to many modified prostaglandins, not readily obtainable by other synthetic schemes.

We wish to report a synthesis of dl-11-deoxy-PGEl (9&) which illustrates

📜 SIMILAR VOLUMES

A biogenetic approach to the synthesis o
A biogenetic approach to the synthesis of a prostanoid precursor.
✍ E.J. Corey; G.W.J. Fleet; Michiharu Kato 📂 Article 📅 1973 🏛 Elsevier Science 🌐 French ⚖ 221 KB

The endoperoxide II has been shown to be a key intermediate m the synthesis of primary (E and F) prostaglandins from C20 unsaturated fatty acids such as all cis-eicosa-8,11,14-trienoic acid.

A new approach to prostanoids
A new approach to prostanoids
✍ L.K. Truesdale; D. Swanson; R.C. Sun 📂 Article 📅 1985 🏛 Elsevier Science 🌐 French ⚖ 152 KB
A unified approach to prostanoid and cor
A unified approach to prostanoid and corticosteroid synthons
✍ Steven D. Burke; David R. Magnin; Jeffrey A. Oplinger; Julia P. Baker; Ahmed Abd 📂 Article 📅 1984 🏛 Elsevier Science 🌐 French ⚖ 321 KB

Synthons for 11-deoxyprostanoids and II-ketosteroids are available via intramolecular Diels-Alder reactions between oxygenated dienes and attached butenolides. Because of their biological significance, scarcity, and structural diversity, the prostanoid and steroid hormonal agents have held the atte