A considerable effort has been devoted to synthetic studies of natural and modified prostaglandinsL'\*. We have been engaged in a research programme having as its objective a new chemical synthesis that would allow access to natural prostaglandins as well as to many modified prostaglandins, not read
A biogenetic approach to the synthesis of a prostanoid precursor.
β Scribed by E.J. Corey; G.W.J. Fleet; Michiharu Kato
- Publisher
- Elsevier Science
- Year
- 1973
- Tongue
- French
- Weight
- 221 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
The endoperoxide II has been shown to be a key intermediate m the synthesis of primary (E and F) prostaglandins from C20 unsaturated fatty acids such as all cis-eicosa-8,11,14-trienoic acid.
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## Abstract Puerarone was synthesized using chalcone oxidation with thallium (III) trinitrate and chromenation of the resulting isoflavone using 3βhydroxyisovaleraldehyde dimethylacetal. The key demethylation step was achieved with boron tribromide.
The b ynthu.b 06 the enanaXomehic&Yy puke m&n bide-chain .&A dedtibed &torn P-guLonok?actone.
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