A Synthon Approach to Spiro Compounds
β Scribed by Rosy Pradhan; Manabendra Patra; Ajaya K. Behera; Bijay K. Mishra; Rajani K. Behera
- Publisher
- John Wiley and Sons
- Year
- 2006
- Weight
- 15 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0931-7597
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β¦ Synopsis
Abstract
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Synthons for 11-deoxyprostanoids and II-ketosteroids are available via intramolecular Diels-Alder reactions between oxygenated dienes and attached butenolides. Because of their biological significance, scarcity, and structural diversity, the prostanoid and steroid hormonal agents have held the atte
Spiro-fused indanones were constructed using a [4 + 2]-cycloaddition approach from a-methylene indanone dienophiles, which were elaborated from 4-chromanone in a number of steps including a key rearrangement process. This type of spiro-fused structure forms the central core ring system found in natu