A two-step, one-pot enzymatic synthesis of ampicillin from penicillin G potassium salt
β Scribed by Li-Li Du; Qi Wu; Chun-Xiu Chen; Bo-Kai Liu; Xian-Fu Lin
- Book ID
- 113804440
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 456 KB
- Volume
- 58
- Category
- Article
- ISSN
- 1381-1177
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract A cascade of two enzymatic transformations is employed in a oneβpot synthesis of cephalexin. The nitrile hydratase (from __R. rhodochrous__ MAWE)βcatalyzed hydration of Dβphenylglycine nitrile to the corresponding amide was combined with the penicillin G acylase (penicillin amidohydrola
A new procedure for the synthesis of primary acylureas from cyanamide and a variety of carboxylic acids is described. Under mild reaction conditions, the products were obtained in good yield from commercially available starting materials.