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A two-stage algorithm for designing phase I cancer clinical trials for two new molecular entities

✍ Scribed by Zheng Su

Book ID: 116350851
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 120 KB
Volume: 31
Category: Article
ISSN: 1551-7144
DOI: 10.1016/j.cct.2009.10.004

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## Abstract A two‐stage design is proposed to choose among several experimental treatments and a standard treatment in clinical trials. The first stage employs a selection procedure to select the best treatment, provided it is better than the standard. The second stage tests the hypothesis between