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A traceless solid-phase synthesis of pteridines

✍ Scribed by Colin L. Gibson; Salvatore La Rosa; Colin J. Suckling

Publisher
Elsevier Science
Year
2003
Tongue
French
Weight
109 KB
Volume
44
Category
Article
ISSN
0040-4039

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✦ Synopsis

The linking of pyrimidines to polystyrene supports via either a 2-or 4-thioether provides access to pteridines through solid-phase synthesis. Oxidative cleavage (dimethyldioxirane) followed by nucleophilic substitution by amines, azide, or water completes a traceless synthesis of pteridines.

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