Traceless solid-phase synthesis of hydroxylated cyclopentenones
β Scribed by Christos I. Stathakis; John K. Gallos
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- French
- Weight
- 166 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
The linking of pyrimidines to polystyrene supports via either a 2-or 4-thioether provides access to pteridines through solid-phase synthesis. Oxidative cleavage (dimethyldioxirane) followed by nucleophilic substitution by amines, azide, or water completes a traceless synthesis of pteridines.
A solid-phase traceless synthesis of tetrahydroquinoxalines with three combinatorial steps is reported. An aldehyde functionalized polystyrene resin was reductively aminated by amino alcohols, and then the resin bound secondary amines were reacted with o-fluoronitrobenzenes. The hydroxy group was me