The linking of pyrimidines to polystyrene supports via either a 2-or 4-thioether provides access to pteridines through solid-phase synthesis. Oxidative cleavage (dimethyldioxirane) followed by nucleophilic substitution by amines, azide, or water completes a traceless synthesis of pteridines.
A solid phase traceless synthesis of quinoxalinones
✍ Scribed by Viktor Krchňák; Lajos Szabo; Josef Vágner
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- French
- Weight
- 158 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
A solid-phase traceless synthesis of tetrahydroquinoxalines with three combinatorial steps is reported. An aldehyde functionalized polystyrene resin was reductively aminated by amino alcohols, and then the resin bound secondary amines were reacted with o-fluoronitrobenzenes. The hydroxy group was me
A traceless solid-phase synthesis of 2-imidazolones has been developed. Polymer-bound glycerol resin was reacted with bromoacetaldehyde diethyl acetal to give the cyclic acetal bromide on the solid support. Amination of the resin-bound acetal bromide followed by urea formation by reaction with isocy