✦ LIBER ✦

A traceless solid-phase synthesis of 2-imidazolones

✍ Scribed by Jie-Fei Cheng; Christopher Kaiho; Mi Chen; Thomas Arrhenius; Alex Nadzan

Publisher: Elsevier Science
Year: 2002
Tongue: French
Weight: 98 KB
Volume: 43
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(02)00897-3

No coin nor oath required. For personal study only.

✦ Synopsis

A traceless solid-phase synthesis of 2-imidazolones has been developed. Polymer-bound glycerol resin was reacted with bromoacetaldehyde diethyl acetal to give the cyclic acetal bromide on the solid support. Amination of the resin-bound acetal bromide followed by urea formation by reaction with isocyanates afforded the resin-bound urea acetals. The aldehyde urea intermediate, which was released from the resin upon treatment with TFA, immediately cyclized to afford the desired 2-imidazolones in good yield and purity.

📜 SIMILAR VOLUMES

A traceless solid-phase synthesis of pte

A traceless solid-phase synthesis of pteridines

✍ Colin L. Gibson; Salvatore La Rosa; Colin J. Suckling 📂 Article 📅 2003 🏛 Elsevier Science 🌐 French ⚖ 109 KB

The linking of pyrimidines to polystyrene supports via either a 2-or 4-thioether provides access to pteridines through solid-phase synthesis. Oxidative cleavage (dimethyldioxirane) followed by nucleophilic substitution by amines, azide, or water completes a traceless synthesis of pteridines.

A solid phase traceless synthesis of qui

A solid phase traceless synthesis of quinoxalinones

✍ Viktor Krchňák; Lajos Szabo; Josef Vágner 📂 Article 📅 2000 🏛 Elsevier Science 🌐 French ⚖ 158 KB

A solid-phase traceless synthesis of tet

A solid-phase traceless synthesis of tetrahydroquinoxalines

✍ Viktor Krchňák; Jennifer Smith; Josef Vágner 📂 Article 📅 2001 🏛 Elsevier Science 🌐 French ⚖ 89 KB

A solid-phase traceless synthesis of tetrahydroquinoxalines with three combinatorial steps is reported. An aldehyde functionalized polystyrene resin was reductively aminated by amino alcohols, and then the resin bound secondary amines were reacted with o-fluoronitrobenzenes. The hydroxy group was me

Traceless Solid-Phase Organic Synthesis

✍ Paul Blaney; Ronald Grigg; Visuvanathar Sridharan 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 24 KB 👁 1 views

Traceless Solid-Phase Synthesis of Trifl

Traceless Solid-Phase Synthesis of Trifluoromethylarenes

✍ Dipl.-Chem. Marion Döbele; Dr. Matthias S. Wiehn; Prof. Dr. Stefan Bräse 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 373 KB 👁 2 views

Traceless solid phase synthesis of 2,3-d

Traceless solid phase synthesis of 2,3-disubstituted indoles

✍ Adrian L. Smith; Graeme I. Stevenson; Christopher J. Swain; JoséL. Castro 📂 Article 📅 1998 🏛 Elsevier Science 🌐 French ⚖ 234 KB

An efficient method for the traceless solid phase synthesis of 2,3-disubstituted indoles using a THP linker and a Pd(0)-mediated annulation of 2-iodoaniline and acetylenes is reported.