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A Traceless Approach for the Parallel Solid-Phase Synthesis of 2-(Arylamino)quinazolinones

✍ Scribed by Yu, Yongping; Ostresh, John M.; Houghten, Richard A.


Book ID
120458081
Publisher
American Chemical Society
Year
2002
Tongue
English
Weight
51 KB
Volume
67
Category
Article
ISSN
0022-3263

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A traceless solid-phase synthesis of 2-i
✍ Jie-Fei Cheng; Christopher Kaiho; Mi Chen; Thomas Arrhenius; Alex Nadzan πŸ“‚ Article πŸ“… 2002 πŸ› Elsevier Science 🌐 French βš– 98 KB

A traceless solid-phase synthesis of 2-imidazolones has been developed. Polymer-bound glycerol resin was reacted with bromoacetaldehyde diethyl acetal to give the cyclic acetal bromide on the solid support. Amination of the resin-bound acetal bromide followed by urea formation by reaction with isocy