The linking of pyrimidines to polystyrene supports via either a 2-or 4-thioether provides access to pteridines through solid-phase synthesis. Oxidative cleavage (dimethyldioxirane) followed by nucleophilic substitution by amines, azide, or water completes a traceless synthesis of pteridines.
✦ LIBER ✦
Solid-Phase Synthesis of Isocoumarins: A Traceless Halocyclization Approach
✍ Scribed by Peuchmaur, Marine; Lisowski, Vincent; Gandreuil, Céline; Maillard, Ludovic T.; Martinez, Jean; Hernandez, Jean-François
- Book ID
- 121302220
- Publisher
- American Chemical Society
- Year
- 2009
- Tongue
- English
- Weight
- 470 KB
- Volume
- 74
- Category
- Article
- ISSN
- 0022-3263
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