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A Traceless Approach for the Solid-Phase Synthesis of 6-Amino-1,3,5-triazine-2,4-diones

โœ Scribed by Yu, Yongping; Ostresh, John M.; Houghten, Richard A.


Book ID
120515202
Publisher
American Chemical Society
Year
2004
Tongue
English
Weight
27 KB
Volume
6
Category
Article
ISSN
1520-4766

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Solid-phase synthesis of 1,2,4-triazolid
โœ Kyung-Ho Park; Linda J Cox ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 56 KB

A traceless synthesis of 1,2,4-triazolidine-3,5-diones has been achieved through cyclo-elimination from solid-phase. This traceless cyclo-elimination release step is induced by catalytic amount of base or by simply refluxing the urea carbamate intermediate.