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A Synthetic Lectin for O-Linked β-N-Acetylglucosamine

✍ Scribed by Yann Ferrand; Emmanuel Klein; Nicholas P. Barwell; Matthew P. Crump; Jesus Jiménez-Barbero; Cristina Vicent; Geert-Jan Boons; Sampat Ingale; Anthony P. Davis

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
650 KB
Volume
48
Category
Article
ISSN
0044-8249

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✦ Synopsis

Abstract

Changing employment: Receptor 1 binds β‐N‐acetylglucosaminyl (β‐GlcNAc) up to 100 times more strongly than it does glucose. This synthetic lectin shows affinities similar to wheat germ agglutinin (WGA), a natural lectin used to bind GlcNAc. Remarkably, 1 is more selective than WGA. It favors especially the glycoside unit in glycopeptide 2, a model of the serine‐O‐GlcNAc posttranslational protein modification.magnified image

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