Inside Cover: A Synthetic Lectin for O-Linked β-N-Acetylglucosamine (Angew. Chem. Int. Ed. 10/2009)

✍ Scribed by Yann Ferrand; Emmanuel Klein; Nicholas P. Barwell; Matthew P. Crump; Jesus Jiménez-Barbero; Cristina Vicent; Geert-Jan Boons; Sampat Ingale; Anthony P. Davis

• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 536 KB
• Volume: 48
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/anie.200990042

✦ Synopsis

Abstract

Carbohydrates are slippery customers in water. Camouflaged by solvent‐mimicking hydroxy groups, they make challenging targets, even for natural receptors. In their Communication on page 1775 ff., A. P. Davis and co‐workers describe a synthetic receptor that is remarkably effective for the important β‐N‐acetylglucosaminyl (β‐GlcNAC) unit. The affinities of the receptor are good and its selectivities are excellent, even by the standards of natural carbohydrate‐binding proteins.magnified image