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Innentitelbild: A Synthetic Lectin for O-Linked β-N-Acetylglucosamine (Angew. Chem. 10/2009)

✍ Scribed by Yann Ferrand; Emmanuel Klein; Nicholas P. Barwell; Matthew P. Crump; Jesus Jiménez-Barbero; Cristina Vicent; Geert-Jan Boons; Sampat Ingale; Anthony P. Davis


Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
531 KB
Volume
121
Category
Article
ISSN
0044-8249

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✍ Yann Ferrand; Emmanuel Klein; Nicholas P. Barwell; Matthew P. Crump; Jesus Jimén 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 536 KB

## Abstract **Carbohydrates are slippery customers** in water. Camouflaged by solvent‐mimicking hydroxy groups, they make challenging targets, even for natural receptors. In their Communication on page 1775 ff., A. P. Davis and co‐workers describe a synthetic receptor that is remarkably effective f

A Synthetic Lectin for O-Linked β-N-Acet
✍ Yann Ferrand; Emmanuel Klein; Nicholas P. Barwell; Matthew P. Crump; Jesus Jimén 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 650 KB

## Abstract **Changing employment**: Receptor **1** binds β‐__N__‐acetylglucosaminyl (β‐GlcNAc) up to 100 times more strongly than it does glucose. This synthetic lectin shows affinities similar to wheat germ agglutinin (WGA), a natural lectin used to bind GlcNAc. Remarkably, **1** is more selectiv