✦ LIBER ✦

β-Amyloid precursor protein is modified with O-linked N-acetylglucosamine

✍ Scribed by L. S. Griffith; M. Mathes; B. Schmitz

Publisher: John Wiley and Sons
Year: 1995
Tongue: English
Weight: 1022 KB
Volume: 41
Category: Article
ISSN: 0360-4012
DOI: 10.1002/jnr.490410214

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✦ Synopsis

Evidence is presented that APP is modified with N-acetylglucosamine linked to cytoplasmic serine or threonine residues (0-GlcNAc). This is the first report of a plasma membrane protein modified with this carbohydrate. It has been postulated that this modification, which is ubiquitous in all organisms studied to date except bacteria (Haltiwanger et al.

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