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A synthesis of 5-amino- and 5-hydroxy-l-ethyl-1,4-dihydrio-4-oxo-3-quinolinecarboxylic acids and their derivatives

โœ Scribed by Yasumitsu Tamura; Masanobu Fujita; Ling Ching Chen; Kyoji Ueno; Yasuyuki Kita


Book ID
112126686
Publisher
Journal of Heterocyclic Chemistry
Year
1982
Tongue
English
Weight
557 KB
Volume
19
Category
Article
ISSN
0022-152X

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A series of substituted 1-cyclopropyl-6-fluoro-1, 4-dihydro-5-methyl-4-oxo-3-quinoline carboxylic acids was synthesized and tested for their in vitro and in vivo antibacterial activity. The introduction of a methyl group at the 5-position of quinoline nucleus enhanced characteristically the antibact