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Studies on quinoline derivatives and related compounds. 5. Synthesis and antimicrobial activity of novel 1-alkoxy-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids

โœ Scribed by Agui, Hideo; Mitani, Tohru; Izawa, Akio; Komatsu, Toshiaki; Nakagome, Takenari


Book ID
111869803
Publisher
American Chemical Society
Year
1977
Tongue
English
Weight
735 KB
Volume
20
Category
Article
ISSN
0022-2623

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โœ Hisashi Miyamoto; Hiroshi Yamashita; Hiraki Ueda; Hisashi Tamaoka; Kazunoli Ohmo ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 677 KB

A series of substituted 1-cyclopropyl-6-fluoro-1, 4-dihydro-5-methyl-4-oxo-3-quinoline carboxylic acids was synthesized and tested for their in vitro and in vivo antibacterial activity. The introduction of a methyl group at the 5-position of quinoline nucleus enhanced characteristically the antibact